This is the Offical Website
for the Reichert Research Group.
The Reichert Lab is part of the Radiological Sciences Division within
the Mallinckrodt Institute of Radiology at
Washington University School of
Medicine in St. Louis Missouri.
Our
research is focused on the development and utilization of
molecular modeling techniques in order to understand the
interactions of radiometal complexes with biological
systems, and to design new ligands for the coordination of
radiometals to be used for diagnostic imaging and therapy.
This involves many areas of computational chemistry ranging
from development of molecular mechanics forcefields to the
utilization of density functional calculations, and QSAR
studies of radiolabeled pharmaceuticals.
A second research area is the development and utilization
of microfluidics for radiopharmaceuticals. Microfluidic
reactors, consisting of a network of micron-sized channels
(typical dimensions in the range 10 – 300 μm),
filters, separation columns, electrodes and reaction
loops/chambers etched onto a solid substrate, are now
emerging as an extremely useful technology for the
intensification and miniaturization of chemical processes.
The ability to manipulate, process and analyze reagent
concentrations and reaction interfaces in both space and
time within the channel network of a microreactor provides
the fine level of reaction control that is desirable in PET
radiochemistry practice.